在使用电子烟的COPD患者中呼出的氧化水平
Andrew Higham1, Augusta Beech2, Dave Singh2
1Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK.
Nitric oxide : biology and chemistry
|March 1, 2024
概括
在COPD前吸烟者中,电子烟的使用不会显著改变部分排气的氧化 (FeNO) 水平,这是肺炎的关键生物标志物. 这一发现表明FeNO仍然是评估这些患者2型炎症的可靠工具.
科学领域:
- 肺部医学 肺部医学
- 呼吸道炎症 呼吸道炎症
- 生物标志物研究 生物标志物研究
背景情况:
- 电子烟的使用越来越普遍,新出现的数据表明有助于炎症效应.
- 分数呼出的氧化 (FeNO) 是2型 (T2) 肺炎的验证生物标志物.
- 长期使用电子烟对慢性阻塞性肺部疾病 (COPD) 患者的FeNO水平的影响尚不清楚.
研究的目的:
- 研究和比较三个组的FeNO水平:使用电子烟的COPD前吸烟者 (COPDE + e-cig),不使用电子烟的COPD前吸烟者 (COPDE) 和目前的COPD吸烟者 (COPDS).
主要方法:
- 横截面研究比较不同COPD患者队列中的FeNO水平.
- 作为主要结果,使用了微分呼出的氧化 (FeNO) 测量.
- 统计分析以确定群体之间的FeNO水平的显著差异.
主要成果:
- 与COPDS (中位数7.6ppb) 相比,COPDE+电子烟 (中位数16.2ppb) 和COPDE (中位数18.0ppb) 的FeNO含量显著更高.
- 在COPDE+电子烟组和COPDE组之间没有观察到FeNO水平的统计学上显著差异 (p > 0.9).
- 电子烟的使用没有改变FeNO的解释,与目前COPD患者的吸烟不同.
结论:
- 电子烟的使用不会干扰FeNO作为COPD前吸烟者的T2炎症生物标志物的实用性.
- 虽然FeNO反应在电子烟和传统香烟之间有所不同,但这并不意味着电子烟是无害的.
- 不同的肺部影响可能是由于电子烟与可燃烟草制品的化学成分的差异.
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