化学基因XCL1作为怀孕激素,可以为后代编程先天的焦虑
Rosa J Chen1, Anika Nabila1, Judit Gal Toth1
1Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA.
Brain, behavior, and immunity
|March 1, 2024
概括
怀孕激素XCL1对于胎盘发育和男性后代至关重要.
科学领域:
- 神经免疫学 神经免疫学
- 生殖生物学 生殖生物学
- 发育神经科学的发展神经科学.
背景情况:
- 增加的母细胞因子与后代神经精神疾病风险有关.
- 循环的母细胞因子以前没有被认为对胎儿发育有意义.
- 怀孕期间局部免疫信号的作用仍未得到充分研究.
研究的目的:
- 在怀孕期间调查T/NK细胞化学毒性细胞因子XCL1的作用.
- 为了确定XCL1是否超出了局部免疫信号的功能,可能作为怀孕激素.
- 评估XCL1对胎盘发育和后代行为的影响.
主要方法:
- 在整个怀孕期间,在母亲的血中测量了循环XCL1水平.
- 使用了一种遗传5HT1A受体缺乏的小鼠模型和抗XCL1抗体.
- 评估胎儿胎盘发育和分析男性后代的接近避开行为,先天的焦虑和压力反应.
主要成果:
- 循环中的XCL1表现出妊娠中期的上升和下降,偏离低妊娠水平.
- 缺陷中的XCL1升高或抗体中和后增加的胎盘损伤因子.
- 患有XCL1减弱的母体的后代表现出增加的先天焦虑和应激反应能力.
结论:
- 化基因XCL1充当怀孕激素,对胎盘正常发育至关重要.
- 母亲XCL1信号传递对于调节男性后代的情绪行为和应激反应至关重要.
- 化基因代表了一种新型的怀孕激素类别,影响胎儿的发育和行为.
更多相关视频
06:39Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
3.1K
04:20Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
Published on: July 12, 2024
1.6K
相关概念视频
Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
Inheritance of Chromatin Structures
6.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.2K
Hypothalamic-Pituitary Axis
60.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.0K
Chemotaxis and Direction of Cell Migration
3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K
Genomic Imprinting and Inheritance
34.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.4K
