抗结石病的活性和缓解的草药的安全性:基于果结石模型的比较研究
Yi Lu1, Zeliang Wu2, Zhengxi Du2
1Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China; Faculty of Medicinal Plant and Pharmacognosy, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Journal of ethnopharmacology
|March 1, 2024
概括
这项研究使用果模型确定了传统中医药中强效的抗尿病草药. 包括Herba Nephrolepidis在内的几种草药在治疗结石方面表现出有效性和安全性.
科学领域:
- 民族医学和药理学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药物发现 药物发现 药物发现
背景情况:
- 尿病是一种普遍存在的全球性泌尿病状况,具有使用传统中医 (TCM) 治疗的悠久历史.
- 在中医中,用于治疗尿路障碍,如失尿症,出血症和结肠等尿路障碍的许多具有缓解异常性质的草药,这些疾病通常与尿病有关.
- 研究这些民族药理资源可能会产生新的,更安全,更具成本效益的治疗方法.
研究的目的:
- 评估46种中国传统和民间草药的抗尿病疗效和安全性.
- 通过果模型识别有价值的民族医学材料,用于潜在的尿病治疗.
- 探索TCM在治疗结石疾病中的治疗潜力.
主要方法:
- 制备46种草药的水和50%的乙醇提取物.
- 建立一个果 (Drosophila melanogaster) 结石模型,使用氧沙酸作为 lithogenic 剂.
- 通过石块面积比率和石头清理率评估抗尿病能力,用于安全评估的7天死亡率.
主要成果:
- 46种草药中有24种在其水提取物中表现出显著的抗尿病作用.
- 在低死亡率的情况下,Herba Nephrolepidis,Herba Humuli,Herba Desmodii Styracifolii,Cortex Plumeriae Rubrae和Herba Mimosae Pudicae表现出了显著的疗效.
- 只有一小部分植物提取物 (8/46) 在其50%的乙醇提取物中表现出显著的活性.
结论:
- 这项研究成功地从以缓解的特性而闻名的TCM草药中确定了有希望的抗结石病候选者.
- 这项研究强调了传统和民间民族药理学知识对尿病的显著治疗价值.
- 对这些已识别的草药进行进一步的研究可能会导致开发新的抗尿病药物.
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