生活方式干预心力衰竭的有效性与保存的射出小部分:系统性审查和网络元分析
Grace W M Walters1, Jian L Yeo1, Joanna M Bilak1
1Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre, Leicester, UK.
Journal of cardiac failure
|March 1, 2024
概括
高强度间歇训练 (HIIT) 显著改善了心力衰竭与保留射出分数 (HFpEF) 的运动能力和生活质量. 这种生活方式干预超过了临床值,可能是HFpEF患者未充分利用的管理策略.
科学领域:
- 心脏病学和运动生理学
- 心脏衰竭管理的管理
- 生活方式干预研究研究研究
背景情况:
- 心力衰竭与保留喷射分数 (HFpEF) 影响运动耐受性和生活质量 (QoL).
- 包括饮食和运动在内的生活方式干预措施被探索用于管理HFpEF.
- 需要综合证据来比较各种生活方式干预措施在HFpEF中的有效性.
研究的目的:
- 进行网络元分析,评估生活方式干预措施的运动耐受性和HFpEF中的QoL.
- 确定最有效的干预措施,以改善HFpEF患者的峰值氧气吸收 (V̇O2峰) 和QoL.
主要方法:
- 在2022年5月之前,对十个随机对照试验 (RCT) 数据库进行系统搜索.
- 包括以饮食和/或运动干预为重点的RCT在HFpEF中.
- 网络元分析综合了对共同主要结果的数据:V̇O2peak和QoL (MLHFQ).
主要成果:
- 有13项试验,有869名参与者分析了6种不同的干预措施.
- 与对照组相比,所有运动干预措施都改善了VO2峰值;高强度间歇训练 (HIIT) 显示了最大的改善 (2.88毫升/千克/分钟).
- HIIT (-14.45分) 和低强度运动 (LIT) (-11.05分) 显著改善了 QoL (MLHFQ 分数). HIIT在V·O2峰和QOL方面都表现出卓越的有效性.
结论:
- 高强度间歇训练 (HIIT) 是最有效的生活方式干预措施,用于提高HFpEF的运动能力和QoL.
- 通过HIIT观察到的改善超过了临床上具有意义的最低值.
- HIIT代表了HFpEF潜在的未充分利用的管理策略,需要对长期临床结果进行进一步调查.
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