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在感染SARS-CoV-2的小鼠中,恩西特雷尔维尔的预防作用

Haruaki Nobori¹, Keiko Baba¹, Takayuki Kuroda¹

¹Pharmaceutical Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka, 561-0825, Japan.

Antiviral research

|March 1, 2024

概括

口服抗病毒药物恩西特里尔维尔在预防性给予老鼠时,显著保护老鼠免受致命的SARS-CoV-2感染. 这种抗病毒药物在高危人群中显示出预防COVID-19的前景.

科学领域:

病毒学病毒学
药理学药理学是指药理学的学科.
免疫学免疫学免疫学

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 仍然是一个全球健康威胁.
对于高风险人群,迫切需要有效的暴露前预防策略.

研究的目的:

评估口服抗病毒药物恩西特里尔维尔作为抗SARS-CoV-2暴露前预防治疗的疗效.
为了确定针对SARS-CoV-2 3CL蛋白酶的恩西特雷尔维尔的保护作用.

主要方法:

年龄较大的BALB/c小鼠在致命的SARS-CoV-2挑战前24小时接受皮下恩西特雷尔维尔.
评估结果包括体重变化,生存率,肺病毒标位和恩西特里尔维尔血度.

主要成果:

在感染前24小时,单次皮下注射恩西特里尔维尔 (≥64毫克/千克) 剂量显著保护老年小鼠免受致死性和减轻体重减轻.
药理动力学分析表明,在血度≥2.99μg/mL时具有预防作用.
恩西特利维尔抑制了肺部SARS-CoV-2标位,这表明病毒扩散的抑制.

结论:

恩西特里尔维尔在老鼠模型中显示出对SARS-CoV-2感染的显著预防疗效.
这些发现支持ensitrelvir作为COVID-19高风险人群的暴露前预防剂的潜力.

关键词:

抗病毒药物是一种抗病毒药.在 COVID-19 疫情中,恩西特里尔维尔 (Ensitrelvir) 是一种暴露前进行预防性治疗.蛋白酶抑制剂是一种蛋白酶抑制剂.这就是SARS-CoV-2病毒.

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