在健康的纯血马的雌性周期期间便微生物群的变化
Junjie Li1, Haruka Toyama1, Touko Matsumoto1
1Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Journal of equine veterinary science
|March 1, 2024
概括
马匹的肠道微生物组在雌性周期期间保持稳定,只有像Rhodococcus这样的特定细菌表现出与激素波动相关的变化.
科学领域:
- 生殖生物学 生殖生物学
- 微生物组研究的研究.
- 马科的科学 马科的科学
背景情况:
- 肠道微生物群影响宿主生理学,包括生殖功能和激素调节.
- 马匹在雌激素性激素的周期性变化,如雌激素-17β (E2) 和孕激素 (P4),在他们的雌激素周期.
研究的目的:
- 为了研究马的雌性周期和它们的便肠道微生物组合之间的关系.
- 为了确定特定的微生物种群,这些微生物种群的丰富性变化与荷尔蒙波动相关.
主要方法:
- 收集了五只健康的母马的血液和便样本.
- 使用放射性免疫检测 (RIA) 量化血清E2和P4水平.
- 使用16S rRNA测序分析了便肠道微生物组合.
主要成果:
- 整体肠道微生物的丰富性和组成在雌性周期期间是稳定的.
- 线性差异分析效应大小 (LEfSe) 确定了Rhodococcus属在毛囊和状阶段之间差异丰富.
- 特定的少量细菌显示出与荷尔蒙波动相关的变化.
结论:
- 马匹的肠道微生物组合在整个雌性周期中基本一致.
- 雌性周期期间的荷尔蒙波动与特定的低丰度细菌属的变化有关,例如Rhodococcus.
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