多瘤病变:在腰部后部手术后患有腰部疼痛的患者中,可能是病理因素
Dan Pan1, Ke Liu2, Meiyuan Huang3
1Department of Spinal Surgery, Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Medicine
|March 1, 2024
概括
腰部手术后的腰部疼痛与多筋肌肉缩和纤维化有关. 这些多变化与疼痛和残疾相关,这表明它们在后腰部手术后导致LBP.
科学领域:
- 脊柱手术的结果 脊柱手术的结果
- 肌肉骨组织学
- 疼痛研究 疼痛研究
背景情况:
- 有限的组织学数据存在于腰部手术后的多肌肉变化.
- 多种类型突变对临床结果的影响尚不清楚.
研究的目的:
- 为了研究多肌肉形态变化和腰部手术后患者的临床结果之间的关系.
- 探索转化生长因子β1 (TGF-β1) 在多菌变化的作用.
主要方法:
- 组织学分析 (血素和欧,马森染色) 的多肌.
- 免疫组织化学,免疫光和西部斑点来评估TGF-β1的表达.
- 多体截面面积 (CSA),TGF-β1水平,奥斯韦斯特里残疾指数 (ODI) 和视觉模拟尺度 (VAS) 分数之间的相关性分析.
主要成果:
- 与非LBP和对照组相比,多肌CSA在腰部疼痛 (LBP) 组明显较小.
- 在LBP组的多体中,TGF-β1表达升高.
- 多种类型的CSA和TGF-β1表达与ODI和VAS得分有很强的相关性.
结论:
- 在后腰部手术后患有LBP的患者表现出多筋肌肉缩和纤维化.
- 多肌病变的严重程度与功能障碍和疼痛水平密切相关.
- 多筋肌肉变化是后腰部手术后LBP的潜在促成因素.
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