治疗后成像在受体放射性核素治疗中的影响
Surekha Yadav1, Courtney Lawhn-Heath1, Alan Paciorek2
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
概括
在受体放射性核素疗法 (PRRT) 后的定性成像改变了神经内分泌瘤患者的27%的管理. 更高的瘤等级和更早的周期 (2-3) 与这些变化有关,这表明成像.
科学领域:
- 核医学就是核医学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 包括SPECT/CT在内的治疗后成像对于评估受体放射性核酸治疗 (PRRT) 的反应和剂量测量至关重要.
- 图像的定性评估为治疗有效性和PRRT期间的患者管理提供了宝贵的见解.
研究的目的:
- 评估治疗后定性成像对接受PRRT治疗晚期神经内分泌瘤的患者管理的影响.
- 确定由成像检测结果影响的管理变化的频率和类型.
主要方法:
- 对接受PRRT的100名患有晚期分化良好的神经内分泌瘤的患者进行了回顾性分析.
- 在每次循环后24小时内包括治疗后的SPECT/CT成像.
- 查看图表以评估管理变化 (主要/次要) 和与瘤等级的相关性.
主要成果:
- 27%的患者经历了基于定性成像评估的管理变化.
- 78%的受影响患者发生了重大管理变化,主要发生在第二和第三周期后.
- 更高的瘤等级与更高的管理变化率显著相关 (P = 0.006).
结论:
- 治疗后的定性SPECT/CT成像在指导PRRT期间的患者管理中发挥着重要作用.
- 将定性成像集成到PRRT工作流中可以优化治疗策略,特别是在更高度瘤中.
- 早期周期 (2和3) 是观察和对成像信息管理调整采取行动的关键时期.
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