与Sjögren病相关的呼吸道疾病的特征
Loïc Meudec1,2, Marie-Pierre Debray3, Antoine Beurnier4
1Department of Rheumatology, Université Paris-Saclay, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.
RMD open
|March 1, 2024
概括
斯约格伦病 (Sjo-AD) 中的呼吸道疾病与更高的生物活动有关,并影响呼吸道. 虽然肺功能保持稳定,但成像显示进展,而不是间歇性肺病.
科学领域:
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
- 放射学 放射学是一门学科.
背景情况:
- 与Sjögren病 (Sjo-AD) 相关的呼吸道疾病很常见,但与间歇性肺病 (ILD) 相比,研究不足.
- 了解Sjo-AD特征和预后对于患者管理至关重要.
研究的目的:
- 评估与Sjo-AD相关的因素.
- 描述Sjo-AD的临床表现和预后.
- 为了将Sjo-AD患者与没有肺部参与的Sjögren对照进行比较.
主要方法:
- 这是一项涉及9个中心的回顾性多中心研究.
- 包括通过临床医生和CT扫描确认的Sjo-AD患者.
- 与年龄和疾病持续时间相匹配的无肺病史的Sjögren对照进行比较.
主要成果:
- Sjo-AD患者表现出更高的疾病活性 (ESSDAI),主要是由于生物活性.
- Sjo-AD的特征是带有支气管切开和支气管炎症状的多叶杆菌性疾病.
- 诊断时32%的患者患有阻塞性肺病;肺功能在8.7年内保持稳定,但CT扫描显示41%的病变进展,没有进展到Sjo-ILD.
结论:
- 在Sjögren患者中,Sjo-AD与生物活性升高有关.
- 这种情况通常呈现为缓慢进展的扩散性呼吸道疾病,不会导致Sjo-ILD.
- 疾病的进展似乎独立于疾病的整体活动.
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