演变的肝病洞察力从NAFLD到MASLD
Xiude Fan1, Yongfeng Song1, Jiajun Zhao1
1Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; 'Chuangxin China' Innovation Base of stem cell and Gene Therapy for endocrine Metabolic diseases, Jinan, Shandong, 250021, China; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, Shandong, 250021, China.
将非酒精性脂肪性肝病的名称改为与代谢功能障碍相关的脂肪性肝病强调了代谢问题. 这一变化促进了肝脏疾病的个性化治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 肝脏疾病研究 肝脏疾病研究
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个普遍的疾病.
- 人们越来越多地认为NAFLD是代谢功能障碍的表现.
- 名称表需要更新以反映潜在的病理生理学.
研究的目的:
- 引入并证明NAFLD的重新命名为与代谢功能障碍相关的脂肪性肝病 (MASLD).
- 强调新陈代谢功能障碍在脂肪性肝病的发病过程中的关键作用.
- 倡导转向个性化和综合性治疗策略的范式转变.
主要方法:
- 关于NAFLD和代谢综合征的当前文献的综述.
- 对导致脂肪性肝病的病因因素的分析.
- 对现有和拟议的分类法进行比较分析.
主要成果:
- 术语MASLD准确地反映了疾病的代谢基础.
- 改名有助于更好地了解疾病机制.
- 它支持开发有针对性的治疗干预措施.
结论:
- 从NAFLD过渡到MASLD对于推进临床实践和研究至关重要.
- 马斯德强调需要对代谢和肝脏健康进行综合管理.
- 这种重塑品牌为创新的,个性化的方法铺平了道路,以治疗脂肪性肝病.
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