肺癌再辐射:探索利用的修改,治疗方式和与结果相关的因素
Anna Gullhaug1, Vilde D Haakensen2, Dirk De Ruysscher3
1Department of Life Sciences and Health, Oslo Metropolitan University, Faculty of Health Sciences, Oslo, Norway; Department of Oncology, Oslo University Hospital, Oslo, Norway.
肺癌的胸部再辐射 (re-RT) 增加了,使用了更多的治疗意图和像SBRT这样的先进技术. 然而,大多数患者仍然接受了息性重复RT,并且组合剂量计划不常见.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 肺癌 (LC) 患者在初始治疗后经常经历局部区域性衰竭.
- 胸部再辐射 (re-RT) 是由于技术进步而出现的治疗选择.
- 在技术进化的时期,调查LC患者的re-RT趋势至关重要.
研究的目的:
- 分析胸部再辐射 (re-RT) 在肺癌 (LC) 患者的利用和结果.
- 评估技术进步对再技术技术实践的影响.
- 为了确定与在接受重复RT的患者中改善整体生存率相关的因素.
主要方法:
- 一项多中心队列研究,涉及296名肺癌患者,他们在2010-2020年间接受胸部再治疗.
- 从医疗记录和治疗计划系统中提取临床变量和放射治疗 (RT) 数据.
- 总体存活率 (OS) 从完成再RT计算出来.
主要成果:
- 胸部再RT的使用在研究期后半年增加,治疗意图和立体体辐射疗法 (SBRT) 的增加.
- 多变量分析显示,接受治愈性再RT,SBRT,强度调节辐射疗法 (IMRT) 或表现良好状态的患者的总生存率 (OS) 较高.
- 风险器官组合剂量计划 (OAR) 仅适用于三分之一的患者,并且大多低于推指南.
结论:
- 肺癌患者的胸部再RT利用量有所增加,随着SBRT和IMRT等先进技术的日益采用.
- 尽管有治疗意图和先进技术的趋势,但大多数患者仍然接受息性再RT.
- 对处于风险的器官不一致地创建组合剂量计划,凸显了遵守既定指南的差距.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
08:54Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
相关概念视频
Cancer Survival Analysis
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Tumor Immunotherapy
