显著的神经化学影响fMRI响应极性在条纹体
Domenic H Cerri1,2,3, Daniel L Albaugh1,2,3,4, Lindsay R Walton1,2,3
1Center for Animal MRI, the University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nature communications
|March 1, 2024
概括
条形体的光遗传刺激会引起负的功能磁共振成像 (fMRI) 反应,表明血管收缩,即使神经元活动增加. 这突出了血管活性神经递质在解释fMRI信号中的作用.
科学领域:
- 神经科学是一个神经科学.
- 血管生物学 血管生物学
- 神经成像是一种神经成像.
背景情况:
- 状体,一个关键的基底性质组成部分,对行为至关重要.
- 解释功能磁共振成像 (fMRI) 信号需要理解神经元和血管活动.
- 条状神经神经血管合仍然不太了解.
研究的目的:
- 为了研究条状神经元活动和血管反应之间的关系.
- 为了确定带状fMRI信号背后的机制.
- 探索神经递质在条状血管调节中的作用.
主要方法:
- 视觉遗传学刺激大鼠背带状神经元和 afferents.
- 电生理学和光纤测量用于测量神经元活动.
- 电化学测量,体内药理操作和脑切片实验.
- 在老鼠和人类的fMRI.
主要成果:
- 光遗传刺激诱导了阴性条形fMRI反应 (血管收缩),尽管增加了神经元活动.
- 多巴胺释放与条状血管扩张有关.
- 阿片类药物信号临界介导的条状血管收缩.
- 人类研究显示了类似的负 fMRI 反应.
结论:
- 状体fMRI信号受到血管收缩的影响,而不仅仅是血管扩张.
- 血管活性神经传递,特别是阿片类药物信号传递,在条状血管调节中起着至关重要的作用.
- 在条形体中解释fMRI信号需要考虑神经元和血管活动.
相关概念视频
01:24Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).