孕期维生素D和后代骨折风险:这些关联是否持续到青春期中期?
Mia A Percival1, Kara B Anderson2, Julie A Pasco2,3,4,5
1Deakin University, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, VIC, 3220, Australia. mia.percival@research.deakin.edu.au.
European journal of clinical nutrition
|March 1, 2024
概括
怀孕期间母亲的维生素D水平对后代骨折风险的影响因性别而异,持续到青春期. 怀孕早期的维生素D含量较高,减少了男孩的骨折风险,但增加了女孩的骨折风险,这种模式在怀孕后继续存在.
科学领域:
- 生殖健康 生殖健康
- 儿童骨健康问题
- 营养科学 营养科学
背景情况:
- 怀孕期间母亲的维生素D状况与后代的骨健康有关.
- 以前的研究表明,母体25-基维生素-D (25(OH) D对10岁骨折的性别特异性影响.
- 怀孕中维生素D (VIP) 队列为研究这些关联提供了有价值的数据集.
研究的目的:
- 调查母体25~OH) D水平与16岁后代骨折风险之间的关联.
- 为了确定之前观察到的性二态效应是否持续到青春期.
主要方法:
- 在VIP队列中 (在澳大利亚东南部招募的) 475对母婴对的母体血清25...OH) D水平的分析.
- 确定从出生到2019年7月的后代的放射学证实事件骨折.
- 使用考克斯的比例危险模型,对母体年龄,后代性别,出生体重,妊娠时间和抽血季节等共变量进行调整.
主要成果:
- 在孕期早期,较高的母体25~OH) D与男孩的骨折风险降低有关 (HR 0.87),但在女孩的风险增加 (HR 1.10).
- 在妊娠晚期,更高的母体25~OH) D与女孩的骨折风险增加有关 (HR 1.14).
- 这些在早期儿童时期观察到的性别特异性模式持续到青春期.
结论:
- 这项研究证实,在儿童时期观察到的母体维生素D状况与后代骨折风险之间的性别特异关联在青春期继续存在.
- 这些发现凸显了母亲维生素D在后代骨发育和骨折易受性方面的复杂性和性别相关作用.
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