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Updated: Jul 1, 2025

Investigating Protein-protein Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer
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一个细胞模型提供了关于致癌性FOXL2体质变异p.Cys134Trp致病性的见解

Laetitia Herman1, Angélique Amo1, Berangère Legois1

  • 1Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France.

British journal of cancer
|March 1, 2024
PubMed
概括

在颗粒细胞瘤中常见的FOXL2 (分叉盒L2) 基因变异,通过功能增益机制驱动癌症的进展. 这种突变的FOXL2增强了与SMAD3的相互作用,影响了细胞行为.

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