一个肠道微生物签名用于跨癌症类型的组合免疫检查点封锁
Ashray Gunjur1,2, Yan Shao3, Timothy Rozday3
1Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK. ag35@sanger.ac.uk.
Nature medicine
|March 1, 2024
概括
应变级肠道微生物组分析改善了对癌症免疫治疗反应的预测. 将微生物组诊断定制为特定的免疫检查点阻塞方案,而不是癌症类型,可以提高跨不同患者队伍的生物标志物有效性.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点阻塞 (ICB) 显示了患者在癌症治疗中的可变反应.
- 肠道微生物群的组成与ICB反应有关,但一般化的生物标志物是难以捉摸的.
- 以前的研究集中在物种级的微生物丰富度上,忽视了菌株特定的功能变异.
结论:
- 基于微生物组的ICB反应生物标志物在菌株水平上分析时最有效.
- 未来的肠道微生物组诊断和免疫疗法治疗方法的发展应该与ICB治疗方案相适应.
- 这种方法提供了一个更精确的策略,以个人的肠道微生物概况为基础,个性化癌症免疫治疗.
相关概念视频
01:27Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K