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增长因子多模式在治疗人类牙介质干细胞:一个系统的审查

Huiying He¹, Yun-Hsuan Yang¹, Xuesong Yang²

¹School of Stomatology, Jinan University, Guangzhou, 510632, China.

BMC oral health

|March 1, 2024

概括

增长因子 (GFs) 对于调节人类牙间酶干细胞 (MSCs) 至关重要. 多种模式的GF治疗提高了MSC的数量,质量和治疗效果,用于各种应用.

科学领域:

再生医学是一种再生医学.
干细胞生物学干细胞生物学
生物技术是生物技术.

背景情况:

牙介质干细胞 (MSC) 的使用越来越多,需要确保其数量,质量和有效性的方法.
增长因子 (GF) 是干细胞生存和分化的关键调节者,通过特定的细胞受体起作用.
有限的研究存在于各种GF对牙科MSCs的具体影响.

研究的目的:

系统地审查关于使用单个或多个GF与人类牙科MSCs的有效性和机制的文献.
了解不同的GF如何影响牙科MSC,承认不同的MSC类型有独特的反应.

主要方法:

使用Web of Science和PubMed进行了系统的文献搜索.
纳入了2014年至2023年期间发表的研究,重点关注GF和人类牙科MSC,遵守PRISMA 2020指南.
文章选择于2023年7月15日完成.

主要成果:

在3,867篇最初的文章中,有56篇被选中进行审查,重点关注GF对人类牙MSC的影响.
32项研究研究了单个GF,24项研究研究了多个GF.
GFs在人类牙科MSCs中发挥了多方面的监管作用.

结论:

组合GF治疗有效调节人类牙科MSCs.
多种模式的GF应用提高了干细胞的质量,数量和整体治疗结果.

关键词:

牙中介细胞干细胞牙中介细胞干细胞增长因子受体增长因子受体增长因素增长因素

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