在危急疾病期间,高氧对肠道的影响
Ninan Dai1, Juan Gu2,3, Yanhong Luo4
1Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Critical care (London, England)
|March 1, 2024
概括
过度的氧气疗法可能会损害肠道微生物群,导致失能和屏障功能障碍. 优化氧气水平对于重症患者至关重要,以防止高氧化引起的肠道损伤.
科学领域:
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 患者通过吸入或体外膜氧化 (ECMO) 接收氧气,风险是系统性或局部性高氧.
- 胃肠道接触过多的氧气,可能会通过反应性氧物种引起器官损伤.
- 肠道微生物组的改变与严重疾病有关,氧气水平显著影响肠道微生物生理和生态.
研究的目的:
- 审查临床前证据,以了解过量的氧气如何影响胃肠道和肠道微生物群.
- 讨论氧气在关键疾病中对肠道健康的影响,包括需要吸入氧气和静脉动脉ECMO的疾病.
- 突出进一步研究和优化氧化策略的需要.
主要方法:
- 对新出现的临床前证据进行系统审查.
- 对研究过氧对肠道生理学和微生物群的影响的分析.
- 讨论各种重症监护场景中的临床影响.
主要成果:
- 过度吸入氧气会导致扩散性小性损伤,肠道屏障功能障碍和失能症.
- 肠道失生症的特点是氧气耐受性病原体的扩张 (例如,Enterobacteriaceae) 和有益微生物的枯竭 (例如,Muribaculaceae).
- 关于氧气在关键疾病中对肠道的影响的证据是有争议的,目前没有共识.
结论:
- 针对近生理氧化,可以预防高氧化引起的肠损伤和中肠缺血.
- 根据临床背景,最佳氧气目标可能会有所不同,包括急性缺氧,新生儿,胃肠道手术或ECMO支持.
- 需要进一步的研究来优化重症患者的氧化策略,平衡高氧和缺氧的风险.
关键词:
它们是Enterobacteriaceae的细菌.解剖学上的泄漏.双循环的双循环.这是一个很棒的体验,Gut Gut Gut Gut.我们的肠道微生物组.过度氧化症 (hyperoxia) 是一种过度氧化症.中肠缺血症中肠缺血症是什么死性肠道结肠炎 (NECO) 是一种氧气疗法是一种氧气疗法.这就是VA-ECMO.更多相关视频
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