结肠镜检查后肠道微生物群动态和便SCFA:加速通过Clostridium butyricum稳定微生物群
Zhenhui Chen1, Lu Yu2, Jiaxin Liu1
1Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Journal of translational medicine
|March 1, 2024
概括
在结肠镜检查后补充Clostridium butyricum有助于更快地恢复肠道微生物群和短链脂肪酸 (SCFA). 这种益生菌干预加速了手术后的肠道微生物平衡.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢学 代谢学 代谢学
背景情况:
- 结肠镜检查是一种常见的诊断程序,可以引起腹等胃肠道障碍.
- 了解结肠镜对肠道微生物群和代谢物的影响,对于患者的康复至关重要.
研究的目的:
- 为了研究肠道微生物群的动态和结肠镜检查后的代谢变化.
- 评估Clostridium butyricum补充剂在恢复结肠镜后肠道微生物组平衡方面的有效性.
主要方法:
- 使用16S rRNA测序和GC-MS.分析肠道微生物群和便短链脂肪酸 (SCFA).
- 在Clostridium butyricum菌株中对buk基因 (丁酸盐激酶) 的生物信息分析.
主要成果:
- 在健康人群中,肠道微生物群和SCFA水平在结肠镜检查后的第7天恢复.
- 补充Clostridium butyricum加速了肠道微生物群和SCFA恢复,在第3天稳定.
- 生物信息分析表明,Clostridium物种可以有效地产生黄油酸.
结论:
- 补充Clostridium butyricum表明有望提高结肠镜检查后的肠道恢复.
- 建议在结肠镜检查后对Clostridium butyricum进行例行临床考虑.
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