功能连接的差异模式在震主导帕金森病和基本震加
Shweta Prasad1, Jitender Saini1, Rose Dawn Bharath1
1Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health & Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, 560029, India.
Journal of neural transmission (Vienna, Austria : 1996)
|March 2, 2024
概括
这项研究揭示了震主导帕金森病 (TDPD) 和基本震加 (ETP) 中明显的脑网络变化. TDPD显示基底-甲状腺皮层连接性发生变化,而ETP涉及大脑-甲状腺皮层通路,表明发生的重叠机制.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 震主导的帕金森病 (TDPD) 和基本震加 (ETP) 是由震为特征的常见神经疾病.
- 基本状体 - - 甲状腺皮层 (BGTC) 和大脑 - - 甲状腺皮层 (CTC) 网络与震产生有关,但它们在TDPD和ETP中的具体作用尚不清楚.
研究的目的:
- 调查和比较TDPD和ETP患者在BGTC和CTC网络中的功能连接性改变.
- 探索这些疾病中震严重程度和功能连接性之间的关系.
主要方法:
- 休息状态功能性MRI (fMRI) 用于从25名TDPD患者,25名ETP患者和22名健康对照 (HC) 获得大脑活动数据.
- 在BGTC和CTC网络上进行了基于种子到voxel的功能连接分析.
- 法恩-托洛萨-马林震评级尺度 (FTMRS) 与连接措施相关.
主要成果:
- 与HC相比,TDPD患者表现出与前中心和后中心旋转的小脑连接性下降.
- 与HC相比,ETP患者与皮皮质,前骨和骨的状连接性下降.
- TDPD显示BGTC与默认模式网络 (DMN) 的连接性增加,小脑连接性降低,而ETP显示状连接性改变,与震严重程度相关.
结论:
- 该研究表明,BGTC和CTC网络在TDPD和ETP中的参与程度不同,TDPD显示BGTC网络参与度更高,ETP显示大脑小脑网络参与度更高.
- 在ETP中观察到的色参与表明BGTC网络在其病变发生过程中发挥了作用.
- 这些发现表明TDPD和ETP之间的震产生潜在机制的潜在相似之处.
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