患有囊性纤维化症的儿童的加勒-3水平
Dilber Ademhan Tural1, Nagehan Emiralioglu2, Senay Akin3
1Department of Pediatric Pulmonology, Ankara Bilkent City Hospital, Ankara, Turkey. dilberademhan@gmail.com.
European journal of pediatrics
|March 2, 2024
概括
与健康儿童相比,患有囊性纤维化 (CF) 的儿童显示血清中加列-3水平升高. 这个生物标志物.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 加勒-3与各种器官的慢性炎症和纤维化有关.
- 囊性纤维化 (CF) 肺部疾病的特征是阻塞,感染和炎症.
- 加勒-3正在成为炎症和纤维状况中的潜在生物标志物.
研究的目的:
- 在患有囊性纤维化症的儿科患者中研究血清加列-3的作用.
- 为了比较CF患者和健康对照者的加勒-3度.
- 探索加勒-3水平和CF中的临床参数之间的相关性.
主要方法:
- 这是一项涉及143名CF患者和30名健康儿童的横截面病例对照研究.
- 使用ELISA测量血清和唾液中的加列-3,IL-17A,IL-8和中性粒细胞弹性酶 (NE).
- 统计分析用于比较群体并评估与年龄,BMI和肺功能之间的相关性.
主要成果:
- 血清加列-3和NE度在CF患者中明显高于对照组.
- 血清加列-3水平与CF儿童的年龄和体重指数 (BMI) 有积极的相关性.
- 吐中甲基-3与FEV1和FVC等肺功能参数呈负相关性.
结论:
- 患有CF的儿童表现出血清中加勒-3水平的增加,这表明它与疾病有关.
- 在CF患者的血清加列-3水平受年龄,性别和BMI的影响.
- 唾液中的加列丁-3水平与囊性纤维化病的肺功能减弱相关.
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