萨尔科佩尼亚和虚弱对脑转移患者结局的影响
Mervyn Jun Rui Lim1, Zheting Zhang2, Yilong Zheng3
1Division of Neurosurgery, National University Hospital, Singapore, Singapore. mervynlim@u.nus.edu.
Journal of neuro-oncology
|March 2, 2024
概括
在脑瘤患者中,由缩小的psoas肌肉区域和虚弱增加死亡率和住院治疗的标志性的sarcopenia. 临床虚弱度量 (CFS) 和肌肉测量可以帮助评估手术风险.
科学领域:
- 在瘤学瘤学.
- 神经外科 神经外科
- 老年病的医生 老年病的医生
背景情况:
- 肉症和脆弱性与癌症患者的不良结果有关.
- 关于它们对脑转移患者的影响的数据有限.
研究的目的:
- 为了研究萨尔科佩尼亚和虚弱对经过手术切除脑转移的患者临床结果的影响.
主要方法:
- 对145名手术切除脑转移 (2011-2019) 的患者进行了回顾性分析.
- 测量了psoas肌肉的横截面积和骨的厚度.
- 使用临床虚弱度量表 (CFS) 评估术前和术后的虚弱.
- 考克斯和线性回归分析用于死亡率,复发和住院时间.
主要成果:
- 减少的psoas截面面积独立预测了更高的死亡率 (HR=2.68) 和复发 (HR=2.31).
- 手术后的CFS独立预测了更高的死亡率 (HR=1.88).
- 手术后的CFS (β=15.69) 和CFS的增加 (β=11.71) 与更长的住院时间有关.
结论:
- 肌区域和术后脆弱性是手术治疗的大脑转移中死亡的重要风险因素.
- 虚弱影响住院时间,突出了手术前评估的必要性.
- 测量psoas肌肉面积和CFS可以帮助分层风险的手术候选人.
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