使用在家自行收集的干血斑点来检测梅毒,人体免疫缺陷病毒,C型肝炎和B型肝炎病毒感染,并测量肌酸度
S A Nieuwenburg, S M Bruisten, T Heijman1
1From the Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.
Sexually transmitted diseases
|March 2, 2024
概括
干血点 (DBS) 采样是与男性发生性关系的男性 (MSM) 性健康测试的可行选择,尽管发现了采样挑战和对梅毒和HCV的较低敏感性.
科学领域:
- 临床医学 临床医学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 家庭干血点 (DBS) 采样有可能简化与男性发生性关系 (MSM) 的男性的性健康服务和暴露前预防 (PrEP) 监测.
- 这种方法可以减少对性传播感染 (STI) 查的亲临诊所访问的需要.
研究的目的:
- 为了比较自我收集的DBS样本的诊断性能与传统的静脉穿刺血液样本,用于多种性传播疾病和肌水平.
- 评估DBS在MSM中采样的可接受性,可行性和可用性.
主要方法:
- 来自性病诊所的MSM客户为例行检测提供了周围血液,并获得了用于DBS采集的家庭套件.
- 对DBS样本进行了梅毒,艾滋病毒,HCV,HBV和肌素的分析,灵敏度和特异性根据静脉穿刺结果计算.
- 通过问卷收集了参与者对DBS可接受性,可行性和可用性的反.
主要成果:
- 在410名参与者中,51.5%的人返回了完整的DBS卡.
- 对HIV (100%) 和HBV (100%) 观察到高灵敏度和特异性.
- 梅毒敏感度为90.8%,特异性为84.3%;HCV抗体敏感度为80.0%,特异性为99.2%. DBS肌素测量显示平均增加了5.3μmol/L.
- 未来使用DBS的意愿中位数为5分之4的5.
结论:
- DBS采样是对接受PREP的MSM进行STI测试和肌素监测的潜在可接受方法.
- 在对DBS进行一致的血液采集方面仍然存在挑战,对于梅毒和HCV的敏感性需要改进以获得广泛的临床采用.
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