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-131干预肝功能不全的甲状腺功能过高症:代谢评估

Zhaoxia Luo¹, Yangyang Lei¹, Lingpeng Zeng¹

¹Department of Nuclear Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, PR China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|March 2, 2024

概括

早期的-131 (¹³¹I) 治疗有效地控制了与肝功能不全 (HI) 相关的甲状腺功能增强症. 确定了六个关键的血清代谢生物标志物,用于早期诊断和监测治疗反应.

科学领域:

内分泌学和新陈代谢学
肝病学肝病学是一种肝病学.
核医学就是核医学.

背景情况:

与肝功能不全 (HI) 同时发生的甲状腺功能增强症带来了复杂的临床管理挑战.
对于优化治疗策略和早期诊断生物标志物来改善HI甲状腺功能障碍患者的治疗结果,这是非常必要的.

研究的目的:

为了确定最佳的-131 (¹³¹I) 剂量治疗高甲状腺症在HI的存在.
用UPLC-Q/TOF-MS.识别血清代谢生物标志物,用于早期诊断与HI相关的甲状腺功能增强症.

主要方法:

开发一种小鼠模型,以评估早期干预对生理参数,甲状腺和肝功能的影响.
利用超高性能液体染色学-四极飞行时间质谱法 (UPLC-Q/TOF-MS) 进行代谢物分析和鉴定.
使用MetaboAnalyst分析的代谢数据,通过接受器操作特征 (ROC) 分析验证生物标志物.

主要成果:

早期干预剂量为每克甲状腺组织80μCi¹³¹I,有效控制甲状腺功能升高和改善肝功能障碍.
鉴定了六个关键的血清代谢生物标志物 (L-kynurenine,Taurochenodesoxycholic acid,Glycocholic acid,Phytosphingosine,Tryptamine和Betaine),这些都表明了与HI相关的早期甲状腺功能障碍.
这些已识别的生物标志物在I干预后显示出正常化趋势.

结论:

UPLC-Q/TOF-MS是一种有价值的技术,用于发现代谢生物标志物,用于早期诊断由HI复杂的甲状腺功能障碍.
早期的I干预显示了治疗治疗高甲状腺症与HI的管理和确定代谢生物标志物的正常化.

关键词:

早期干预是早期的干预.甲状腺功能障碍与同时出现的肝功能不全.-131是一种.代谢学代谢学代谢学血清中的生物标志物在UPLC-Q/TOF-MS中使用.

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