弗卢比芬在下喉空间,以预防心脏手术后的术后喉痛:一项随机双盲研究
Maria Calabrese1, Gabriella Arlotta1, Maria Enrica Antoniucci1
1Department of Cardiovascular Sciences, Intensive Care Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Journal of clinical anesthesia
|March 2, 2024
概括
在心脏手术患者中,通过下口服的flurbiprofen有效地减少了术后喉痛和声. 这种新的方法提供了一种安全而无并发症的方法来管理常见的输管相关的不适.
科学领域:
- 麻醉学和重症监护医学
- 手术并发症管理 手术并发症管理
- 药理干预药理干预
背景情况:
- 手术后喉痛 (POST) 和声是气管管道输液后经常出现的问题.
- 需要有效的策略来缓解这些常见的术后并发症,特别是在心脏手术后.
研究的目的:
- 为了评估局部flurbiprofen的疗效,通过气管的 subglottic 端口管理,在预防POST.
- 评估二次结果,包括声,安全性和患者满意度.
主要方法:
- 一个单中心,前性,随机,双盲,安慰剂受控试验.
- 接受选择性心脏手术的71名患者被随机分配到通过下关口接受flurbiprofen或盐水.
- 弗鲁比/盐水在三个关键时间点进行:输管后,ICU入院后和输管前.
主要成果:
- 与安慰剂组 (100%) 相比,flurbiprofen组显示POST和声 (5.9%) 的发生率明显较低.
- 喉疼痛和声的严重性得分在flurbiprofen组在所有测量时间点都显着较低.
- 在这两组中都没有报告任何不良反应,这表明了有利的安全性.
结论:
- 在心脏手术后,通过下喉口重复注射flurbiprofen是减少POST和声的有效策略.
- 这种方法为管理常见的气管管道输液并发症提供了安全和耐受良好的干预措施.
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