相关实验视频
Updated: Jul 1, 2025

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Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
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在帕金森病中,长度大脑变化伴有严重的嗅觉缺陷
Kazuya Kawabata1, Epifanio Bagarinao2, Klaus Seppi3
1Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Parkinsonism & related disorders
|March 2, 2024
概括
帕金森病 (PD) 患有厌氧症 (嗅觉丧失) 的患者表现出更大的脑缩. 同时的REM睡眠行为障碍 (RBD) 加快了这些皮质变化,影响了认知功能.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 嗅觉功能障碍和REM睡眠行为障碍 (RBD) 与帕金森病 (PD) 的认知变化有关.
- 这些关联的神经生物学基础,特别是神经退行模式,尚未完全理解.
- 这项研究调查了早期PD的纵向皮质变化与严重的嗅觉丧失 (厌氧),有或没有可能的RBD.
研究的目的:
- 在早期PD患者中检查纵向皮层缩和稀薄.
- 为了比较患有严重嗅觉缺陷 (厌氧) 的人与没有严重嗅觉缺陷 (厌氧) 的人之间的这些变化.
- 为了研究同步可能的RBD对无氧性PD患者皮质变化的影响.
主要方法:
- 分析了4年来134名新发病患者和49名健康对照患者的纵向MRI数据 (帕金森进展标志物倡议队列).
- 利用线性混合效应模型来评估大脑体积和皮层厚度的变化.
- 患者根据嗅觉功能 (UPSIT分数≤18对于无敏症) 和可能存在的RBD.患者被分类.
主要成果:
- 与没有 anosmia 的患者相比,PD 患有 anosmia 的患者表现出相对hippocampal gyri 和右横 temporal gyrus 的体积和厚度在纵向下降的显著增加.
- 患有并发性厌氧症和可能的RBD的患者表现出皮质体积和厚度的纵向下降更为明显.
- 在阿诺斯米亚+RBD组中的这些加速变化涉及额外的区域:双边前,左下状环,右侧中心环和右前中心环.
结论:
- 在患有厌氧症的早期PD中,缩和稀薄模式涉及关键的认知区域,这可能解释了严重的嗅觉缺陷和认知衰退之间的联系.
- 同时的RBD似乎会加剧帕金森病中皮质变化的速度.
- 这些发现表明,在PD早期,基于嗅觉状态和RBD的不同神经退行性轨迹.
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