长期生存不受食道切除术后并发症的严重程度的影响
Edward J Nevins1, Jakub Chmelo1, Pooja Prasad1
1Northern Oesophagogastric Unit, Royal Victoria Infirmary, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, UK.
消化管切除术后的术后并发症不会影响长期生存. 这项研究发现,无论并发症严重程度如何,生存率没有显著差异,这表明重点应该转向生活质量.
科学领域:
- 在瘤学瘤学.
- 外科手术的结果
- 胃肠道手术 胃肠道手术
背景情况:
- 在过去的30年里,食管切除术的结果有了显著的改善.
- 手术后并发症对食道切除术后的长期生存的影响仍在争论中.
- 这项研究调查了手术前并发症对长期生存的影响.
研究的目的:
- 为了确定手术后并发症是否会影响食道切除术后的长期存活率.
- 分析不同严重程度并发症的生存率.
- 为了确定影响食道切除术后生存的因素.
主要方法:
- 从一个大批量中心对721名食道切除术患者 (2010-2019) 的回顾性分析.
- 根据Clavien-Dindo并发症等级 (0-1,2,3-4) 分类的患者在30天内.
- 排除住院死亡;使用卡普兰-梅尔和日志等级测试分析生存率.
主要成果:
- 在并发症组中,中位生存时间 (50-57个月) 没有显著差异.
- 无论并发症的严重程度如何,在1,3年和5年等同的长期存活率 (p=0.806).
- 生存的独立预测因素是男性性别,查尔森并发症指数和病态阶段.
结论:
- 术前并发症,无论严重程度如何,都不会影响食道切除术后的长期生存.
- 需要进一步的研究来探索食道切除术后的长期生活质量.
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