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一种基于血管衰老相对风险差异的血管年龄估计的新方法

Qingfeng Tang¹, Shiping Liu², Chao Tao²

¹School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; The University Key Laboratory of Intelligent Perception and Computing of Anhui Province, Anqing Normal University, Anqing 246133, China; Anhui Engineering Research Center of Intelligent Perception and Elderly Care, Chuzhou University, Chuzhou 239000, China.

Computers in biology and medicine

|March 2, 2024

概括

这项研究引入了一种估计血管年龄 (VA) 的新方法,该方法可以解释血管衰老 (IDVA) 的个体差异. 这种新的方法改善了心血管疾病风险评估,特别是在年轻人身上.

科学领域:

心血管健康心血管健康
生物医学工程生物医学工程
老年学是一门学科.

背景情况:

当前的血管年龄 (VA) 估计模型依赖于时间年龄 (CA),未能捕捉血管衰老 (IDVA) 的个体差异.
这种限制可能导致不准确的心血管疾病 (CVD) 风险评估.
需要对VA估计采取更个性化的方法.

研究的目的:

开发一种用于估计VA的新方法,该方法包含IDVA.
通过解决基于CA的VA模型的局限性,更准确地评估心血管疾病风险.

主要方法:

引入了血管衰老的相对风险差异 (RRDVA) 来量化IDVA.
开发了一个回归模型,使用CA和两个关键动脉样硬化指标来预测个体PA.
综合RRDVA和CA作为确定新VA的因素.

主要成果:

基于RRDVA的拟议VA显示了与27个间接血管衰老指标的显著相关性.
与CA相比,VA与这些指标的相关性更强.
超过零的RRDVA表示疾病风险增加.

结论:

新的VA估计方法有效地克服了CA在描述IDVA方面的局限性.
这种改进的VA评估可以帮助识别高风险个体,包括年轻人群.
在风险群体中促进健康行为可以通过更准确的VA来促进.

关键词:

时间表年龄年代表年龄预测年龄预测年龄血管衰老中的相对风险差异血管年龄血管年龄评估血管衰老的评估

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