影响废水分析,调查欧洲新兴精神活性物质使用的新趋势
Noelia Salgueiro-Gonzalez1, Frederic Béen2, Lubertus Bijlsma3
1Department of Environmental Health Science, Istituto di Ricerche Farmacologiche Mario Negri - IRCCS, Milan, Italy.
Water research
|March 2, 2024
概括
基于废水的流行病学在12个欧洲城市检测到300多种新的精神活性物质 (NPS) 和芬太尼. 3-甲基甲基 (3-MMC) 的使用率最高,观察到空间和每周的趋势.
科学领域:
- 环境科学 环境科学
- 法医科学 法医科学 法医科学
- 公共卫生 公共卫生
背景情况:
- 新型精神活性物质 (NPS) 对毒品政策和公共卫生构成越来越大的全球挑战.
- 基于废水的流行病学 (WBE) 提供了对物质使用的客观和及时监测.
- 快速出现的NPS需要先进的监控方法.
研究的目的:
- 监测欧洲废水中300多种NPS,芬太尼和诺芬太尼的使用情况.
- 为了确定12个城市NPS消费的空间和时间趋势.
- 评估WBE对跟踪新兴药物趋势的有用性.
主要方法:
- 从12个欧洲城市收集24小时复合影响废水样本 (2021年3月至6月).
- 使用固态提取和液态色谱-质谱学的定量和定性分析.
- 对选定生物标志物的样本内稳定性测试.
主要成果:
- 芬太尼,诺芬太尼和八种NPS被量化,在每个城市中至少检测到三种物质.
- N,N-二甲基三胺和3-甲基甲基 (3-MMC) 是最频繁检测到的NPS.
- 3-MMC表现出最高的质量负载 (高达24.8 mg/天/1000 人口),并显示出明显的每周使用模式.
- 在城市和国家之间观察到NPS使用的空间趋势.
- 从五个类别中确定了七个额外的NPS.
结论:
- WBE有效地监测了欧洲各地新出现的NPS趋势.
- 该研究发现了各种NPS的广泛使用,包括大量的3-MMC消费.
- WBE补充了传统的监测方法,有助于公共卫生保护战略.
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