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不同臭氧制剂在体外对导致母马子宫内膜炎的微生物的影响

Gian Guido Donato¹, Patrizia Nebbia¹, Maria Cristina Stella¹

¹Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, Italy.

|March 2, 2024

概括

臭氧气和臭氧化油对常见的母马子宫内膜炎病原体具有强大的抗菌作用. 这项研究表明,臭氧是抗生素的有希望的替代品,用于治疗由感染引起的马不孕症.

科学领域:

兽医医学兽医医学兽医医学
微生物学微生物学
臭氧疗法是一种臭氧疗法.

背景情况:

感染性子宫内膜炎是母马不孕的主要原因,影响高达60%的不孕动物.
目前的治疗方法包括抗生素,生化剂和子宫洗,人们越来越担心抗生素耐药性.
臭氧的强烈氧化特性表明,它有可能成为治疗子宫内膜炎的抗微生物替代品.

研究的目的:

评估气态臭氧和臭氧化油对导致马内膜炎的关键微生物的体外杀菌和杀菌功效.
为了比较不同配方的臭氧的抗菌活性:气体,臭氧化蒸水和臭氧化油.

主要方法:

实验一:将六种微生物 (大肠杆菌,金黄色杆菌,S. equi,P. aeruginosa,K. pneumoniae,C. albicans) 暴露在不同度和持续时间的O2O3气体中.
实验2:确定臭氧化蒸水和臭氧化油的最小抑制度 (MIC) 和最小杀菌/杀菌度 (MBC/MFC).

主要成果:

气态臭氧 (O2O3) 对所有测试的病原体实现了超过99.9%的微生物减少,证明了时间和度相关的效应.
臭氧化油对所有菌株具有显著的杀菌和杀菌活性 (MIC:12.5-25%v/v,MBC/MFC:12.5-50%v/v).
臭氧化蒸水没有观察到抗菌作用,表明它不适合治疗子宫内膜炎.

结论:

气态臭氧和臭氧化油都在体外有效地对抗导致母马感染性子宫内膜炎的微生物,包括抗生素耐药菌株.
臭氧配方,特别是臭氧化油,是传统抗生素治疗的可行替代品,有可能减少马类繁殖中的抗生素使用.
进一步的体内研究是有必要的,以验证这些有前途的发现,并探索臭氧治疗用于马类子宫内膜炎的临床应用.

关键词:

抗微生物活性抗微生物活性在子宫内膜炎中,子宫内膜炎.在体外 (in vitro) 的情况下.不孕症不孕不育不孕不育不孕不育马雷·马雷·马雷在这里.臭氧臭氧是什么?臭氧臭氧是一种

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