父亲的孕前酒精使用障碍与子女的死亡风险
Priscilla My Lee1, Xin Xu2, Jiang B Du3
1Department of Clinical Medicine-Department of Clinical Medicine-Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
American journal of preventive medicine
|March 2, 2024
概括
怀孕前父亲的酒精使用障碍会增加后代的死亡风险,特别是当接近怀孕时被诊断时. 在酒精方面教育男性.
科学领域:
- 生殖健康 生殖健康
- 公共卫生 公共卫生
- 遗传学和表观遗传学
背景情况:
- 父亲在怀孕前使用酒精与早期怀孕损失有关.
- 父亲饮酒障碍与长期后代死亡率之间的关联尚未得到充分理解.
- 了解这种联系对于公共卫生倡议和家长指导至关重要.
研究的目的:
- 为了调查父亲的怀孕前酒精使用障碍和后代死亡率之间的联系.
- 检查最近的父亲酒精使用障碍诊断如何影响后代死亡率.
- 根据出生第一年后的年龄对子女死亡风险进行分层.
主要方法:
- 全国范围内对1980-2012年1,973,174名丹麦出生者的队列研究.
- 通过丹麦国家患者登记册和处方登记册确定了父性酒精使用障碍.
- 诊断的近期分类为<1年,1至<4年,4至<8年和≥8年;用于估计几率比率 (OR) 和95%置信区间 (CI) 的逻辑回归.
主要成果:
- 父亲饮酒障碍与婴儿死亡率 (OR=1.23,95% CI=1.07-1.42) 和死产 (OR=1.23,95% CI=1.06-1.43) 的增加有关.
- 在出生第一年后,死亡风险增加了28% (95% CI=1.09-1.51).
- 在受孕前1年被诊断为父性酒精使用障碍时,15-40岁的后代的死亡风险增加了85%-111%,感染性和循环疾病的风险更高.
结论:
- 父亲患有怀孕前酒精使用障碍的后代面临着从出生到早期成年期更高的死亡风险.
- 当父亲的酒精使用障碍诊断是最近的 (怀孕1年内) 时,风险显著增加.
- 建议在妊娠前咨询期间提高对父亲饮酒对儿童健康影响的认识和教育.
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