相关实验视频

Updated: Jul 1, 2025

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

贝卡莱因糖蜜眼科溶液:制剂,体外抗菌活性和抗菌机制评估

Jing Zhang¹, Yuhang Li², Sibin Xie³

¹School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.

International journal of pharmaceutics

|March 2, 2024

概括

这项研究开发了一种新的眼科溶液,使用包凯林 (BAI) 装载的糖基米塞尔来增强对眼部感染的抗微生物活性. BAI糖基菌体表现出极好的稳定性,溶解性和眼膜耐受性.

科学领域:

眼科医生眼科眼科
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

由于药物透率有限和潜在的毒性,眼部感染带来了重大挑战.
拜卡莱因 (BAI) 是一种具有抗菌性能的有前途的植物化学物质,但其溶解性差阻碍了眼科应用.
甘油提供了一个潜在的纳米载体系统,可以改善疏水性药物的输送和有效性.

研究的目的:

开发一种新型的使用glycyrrhizin纳米载体的baicalein (BAI) 载入的glycymicelle眼科溶液.
为了评估BAI糖蜜配方的物理化学性质,稳定性和眼睛耐受性.
调查BAI糖蜜眼科溶液对眼部病原体的抗菌潜力和作用机制.

主要方法:

被包装在贝卡莱因 (BAI) 的糖细胞被制定和优化.
物理化学表征包括封装效率,粒子大小,多分散度指数和泽塔潜力.
进行了体外释放,抗氧化活性和抗病原体活性测试.
在子体内进行了眼睛耐受性和角膜透性研究.

主要成果:

经过优化的BAI糖基菌表现出高封装效率 (98.76%),小颗粒大小 (54.38 nm) 和良好的稳定性.
眼科溶液显著改善了BAI的溶解性和体外释放.
在子中没有观察到胆 ?? 膜刺激和良好的眼睛耐受性.
在体内增强的角膜透,在体内增加的抗氧化活性和在体内强大的抗病原体活性被证明.
抗微生物机制包括细菌细胞壁/膜损伤,生物膜破坏和亡.

结论:

成功开发了新型的卡莱因 (BAI) 装载的糖菌眼科溶液.
该配方增强了BAI的溶解性,稳定性,眼睛透性和抗菌有效性.
这种新型纳米载体系统显示出治疗眼睛感染的巨大潜力.

关键词:

抗微生物效应抗微生物效应在 Baicalein 的酒吧里糖里津是什么? 糖里津是什么?机理机制机理机制可溶性溶解度溶解度溶解度

更多相关视频

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

相关概念视频

Hand hygiene

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...

Cholinergic Antagonists: Pharmacokinetics

Cholinergic Antagonists: Pharmacokinetics

Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations, while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...