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Updated: Jul 1, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Published on: April 13, 2015

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与细胞癌相关的DCLRE1B/Apollo生殖基因突变损害了端粒保护

Charlie Bories1, Thomas Lejour1, Florine Adolphe1

  • 1EPHE, PSL Université, Paris, France; UMR 9019 CNRS, Gustave Roussy, Université Paris-Saclay, 114 rue Edouard Vaillant, Villejuif 94800, France.

Biochimica et biophysica acta. Molecular basis of disease
|March 2, 2024
PubMed
概括

阿波罗基因的生殖系突变与遗传性细胞癌 (RCC) 有关. 功能丧失的阿波罗变种损害了DNA修复和端粒完整性,可能导致癌的发展.

关键词:
DCLRE1B/阿波罗号 在线播放修复DNA的修复DNA的修复细菌线突变的发生.细胞癌是细胞癌.泰洛米尔 (Telomere) 是一种电离体.

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