从Trichoderma hamatum b-3分离的二次代谢物及其杀菌活性
Li Huang1, Meng-Dan Liu1, Yi-Wen Hu1
1State Key Laboratory of Southwestern Chinese Medicine Resource, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Fitoterapia
|March 2, 2024
概括
研究人员从Trichoderma hamatum b-3中分离出了新型化合物,包括三二烯衍生物和二二烯. 一种衍生品显示出对Sclerotinia sclerotiorum具有显著的杀菌活性.
科学领域:
- 自然产品 化学 化学
- 菌类学 菌类学是指菌类学.
- 有机化学 有机化学
背景情况:
- 特里科德玛哈马图姆是一种已知的生产生物活性二次代谢产物的真菌.
- 研究真菌代谢物可以导致发现具有潜在应用的新型化合物.
研究的目的:
- 从真菌Trichoderma hamatum b-3中分离和描述新的化学实体.
- 评估隔离化合物对作物致病菌的杀菌潜力.
主要方法:
- 使用色谱技术分离化合物.
- 通过高分辨率电子喷射电离质谱法 (HRESIMS),1D和2D核磁共振 (NMR) 谱法阐明结构.
- 使用马菲分析,电子循环二元化 (ECD) 计算和莫舍尔化方法确定绝对配置.
主要成果:
- 他们分离了四种新化合物:一种三登衍生物 (1),一种比萨博兰模拟物 (2) 和两种二基托皮佩拉辛 (3和4).
- 所有化合物的结构和绝对配置都被明确确定.
- 化合物1在50微克/毫升的剂量下显示出51%的抑制作用对抗Sclerotinia sclerotiorum.
结论:
- 特里科德玛哈马图姆b-3产生各种各样的二次代谢产物.
- 这种新型的三二衍生物显示出有前途的杀菌活性,特别是对抗Sclerotinia sclerotiorum,这表明了农业应用的潜力.
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