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来自Saposhnikovia divaricata的多乙烯及其抗癌活性

Yan Sun¹, Yan Liu¹, Peng Jiang¹

¹School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China; Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Harbin, People's Republic of China.

|March 2, 2024

概括

从Saposhnikovia divaricata的根源中发现了五种新的多乙烯化合物,即sadivaethynes E-I. 化合物9对HEPG2癌细胞表现出中度细胞毒性.

科学领域:

自然产品化学自然产品化学
有机化学有机化学
药理学药理学是指药理学的学科.

背景情况:

萨波什尼科维亚 (Saposhnikovia divaricata) 是一种传统的药用植物.
聚乙烯是一种具有多种生物活性的自然化合物.

研究的目的:

从Saposhnikovia divaricata根中分离和描述新的多乙烯化合物.
评估与人类癌症细胞系对隔离化合物的细胞毒性作用.

主要方法:

使用色谱技术分离化合物.
使用光谱方法 (NMR,MS) 的结构阐明.
使用量子化学计算 (DP4+) 和电子圆二元论 (ECD) 确定绝对配置.
在体外细胞毒性测定对A549和HEPG2细胞系.

主要成果:

分离了五种新的多乙烯,萨迪瓦乙烯E-I (1-5),以及四种已知的化合物.
确定了新化合物的结构和绝对配置.
化合物9对HEPG2细胞具有中度的细胞毒性,IC50值为11.66μM.

结论:

沙波什尼科维亚 (Saposhnikovia divaricata) 是结构多样化的多乙烯的丰富来源.
化合物9显示出作为抗癌剂的潜力,需要进一步调查.

关键词:

A54949 是一个A549的字体.这就是HEPG2的目的.聚乙乙烯的聚乙乙烯.萨波什尼科维亚 (Saposhnikovia divaricata divaricata) 是一种不同种类的植物.

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