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关于IRF6多态度与非综合征裂唇/口腔敏感性之间的关系的数据的全面整合:来自79项病例控制研究

Mohammad Golshan-Tafti¹, Seyed Alireza Dastgheib², Reza Bahrami³

¹Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran.

Journal of stomatology, oral and maxillofacial surgery

|March 2, 2024

概括

干扰素调节因子6 (IRF6) 基因多形态 rs642961 和 rs2235371 与非综合征裂口唇/口腔裂口风险增加有关. 其他IRF6变异在某些人群中显示出特定种族的关联或保护作用.

科学领域:

遗传学遗传学是一个
发展生物学发展生物学
公共卫生公共卫生

背景情况:

带有或没有裂的非综合性裂唇 (NSCL/P) 是一种全球常见的出生缺陷.
之前对IRF6基因多态和NSCL/P的研究显示了相互矛盾的结果.
需要进行全面的元分析,以澄清IRF6变体与NSCL/P风险之间的关联.

研究的目的:

进行元分析,评估IRF6基因多态和NSCL/P之间的关联.
为了更准确地估计特定的IRF6变体所带来的风险.
探索这些协会中潜在的种族和地理差异.

主要方法:

在2023年11月15日之前,对相关文章进行系统的文献搜索.
包括79项病例控制研究,包括14003例病例和19905例控制.
使用综合元分析软件 (版本4.0) 进行的统计分析.

主要成果:

IRF6的rs642961和rs2235371多态性与总体上增加NSCL/P风险有关.
没有发现IRF6 rs2013162和rs2235375.5的显著整体关联.
亚组分析显示了rs642961,rs2235371和rs2235375的种族特异性关联;rs2013162在高加索人和混合人群中发挥了保护作用.

结论:

在一般人群中,rs642961和rs2235371多态度显著增加NSCL/P风险.
IRF6 rs2235375 多态性对NSCL/P易感性的影响可能因种族而异.
IRF6 rs2013162 在高加索,混血和巴西人群中提供保护.

关键词:

裂口唇和口裂口唇和口裂口口唇和口裂口唇.头骨面部头骨面部面部在IRF6基因.进行元分析分析.在NSCL/P 多态性多态性多态性

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