在猫患上围产阶段耳聋后的连接组变化
Alessandra Sacco1, Stephen G Gordon1, Stephen G Lomber2
1Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada.
NeuroImage
|March 2, 2024
概括
聋猫的大脑可塑性显示出有限的白质重塑,这表明适应建立在现有的连接上. 这项研究探讨了猫耳聋模型中的跨模式可塑性.
科学领域:
- 神经科学是一个神经科学.
- 神经可塑性 神经可塑性
- 听觉神经科学 听觉神经科学
背景情况:
- 感官剥夺触发大脑重组,称为补偿性跨模态可塑性.
- 家庭猫的耳聋已经显示出结构性可塑性,但与人类研究相比,基于扩散的研究缺乏.
研究的目的:
- 为了研究白质的结构性适应,在周围生育失聪的猫使用曲谱学.
- 加强猫和人类聋研究之间的方法重叠.
- 为了确定独特的群体连接,并评估聋猫大脑中变化的连接强度.
主要方法:
- 扩散张力成像 (DTI) 和曲谱学被用来分析白质结构.
- 进行了对连接及其强度的全脑分析.
- 聋猫和听猫之间的结构连接的比较.
主要成果:
- 聋猫的整体大脑连接体在很大程度上被保存.
- 鉴定了有限数量的特定组或改变的连接,主要是在感觉网络内和感觉网络之间.
- 在聋猫中观察到五个皮质可塑性和改变沟通的枢纽.
结论:
- 猫的耳聋引起的交叉形态可塑性似乎严重依赖于内在的结构连接.
- 底层白质的显著重塑是有限的,这表明适应能力受到限制.
- 这些发现与对聋猫的现有解剖学痕迹研究一致.
相关概念视频
Accessory Organs
Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
Hair Cells
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Auditory Ossicles
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
Anatomy of the Ear
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
Nose and Nasal Cavity
The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...


