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Updated: Jul 13, 2026

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通过使用PBTK建模促进的逆剂量测量方法,从体外毒性数据中预测利摩尔的体内发育毒性

Manisha Bhateria1, Isha Taneja2, Kajal Karsauliya1

  • 1Toxicokinetics Laboratory, ASSIST and REACT Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow, India.

Toxicology and applied pharmacology
|March 2, 2024
PubMed
概括

以生理学为基础的毒动力学 (PBTK) 建模为辅助的反向剂量计 (PBTK-RD) 从体外数据预测了体内毒性. 这项研究开发了利的PBTK模型,成功地将体外发育毒性转化为体内剂量,用于风险评估.

关键词:
发展性毒性 发展性毒性杀菌剂是一种杀菌剂.评估健康风险 评估健康风险蒙特卡罗模拟的蒙特卡罗模拟在PBTK模型中,不确定性因素是指不确定性的因素.

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