乳酸在巨细胞极化中的作用:致癌的一个因素,也是癌症治疗的有希望的目标
Mobarakeh Ajam-Hosseini1, Romina Heydari2, Milad Rasouli3
1Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Biochemical pharmacology
|March 2, 2024
概括
乳酸会影响巨细胞的两极分化和癌症的进展. 针对乳酸代谢,通过调节瘤微环境和免疫反应,为新型癌症疗法提供了潜力.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
背景情况:
- 瘤微环境 (TME) 在癌症进展中至关重要,巨细胞发挥着关键作用.
- 大细胞两极分化 (M1/M2表型) 显著影响瘤生长和免疫反应.
- 作为代谢副产品的乳酸越来越多地被认为对TME的影响.
研究的目的:
- 在致癌的背景下,系统地审查乳酸在巨细胞两极分化的作用.
- 阐明乳酸生成的机制及其对TME的影响.
- 探索针对乳酸代谢治疗癌症的治疗策略.
主要方法:
- 对有关乳酸,巨细胞两极分化和癌症的现有文献进行系统审查.
- 对将乳酸与巨细胞极化联系起来的分子机制的分析.
- 研究乳酸在瘤生长和免疫调节中的双重作用.
主要成果:
- 乳酸通过癌细胞的糖解产生,改变TME.
- 乳酸积极推动巨细胞的两极分化,影响癌症的进展.
- 乳酸具有双重作用,促进瘤生长和调节免疫反应.
结论:
- 乳酸是癌细胞和巨细胞之间相互作用的关键媒介.
- 操纵乳酸代谢为癌症治疗提供了一个有希望的治疗途径.
- 针对乳酸的生产,运输或对巨细胞的影响可以增强癌症免疫疗法.
相关概念视频
01:38Inflammation
53.4K
Overview
53.4K
02:53Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K