一种新的生物降解质皮肤主食:安全性和功能性评估
Yi-Chia Wu1, Meng-Chien Willie Hsieh2, Wei-Ting Wang3
1Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, 80708, Taiwan; Department of Plastic Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, 80145, Taiwan; Department of Surgery, School of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
Asian journal of surgery
|March 2, 2024
概括
可生物降解的 (Mg) 皮肤紧固件对伤口关闭有希望,与不钢的有效性相匹配,而无需长期保留. 这些新型的基是安全的和生物相容的临床使用.
科学领域:
- 生物材料工程 生物材料工程
- 伤口治愈研究研究 伤口治愈研究
- 手术创新 在外科创新.
背景情况:
- 可生物降解的 (Mg) 皮肤紧固件为传统的不钢紧固件提供了替代品.
- 基料在生物降解性和生物相容性方面具有潜在的优势.
- 目前的临床实践主要使用不钢主.
研究的目的:
- 评估一种新型生物可降解的Mg皮肤主质的安全性和机械性能.
- 为了比较Mg皮肤紧固件与传统不钢紧固件在伤口关闭中的有效性.
主要方法:
- 使用ZK60 Mg合金制造了一种原型Mg皮肤主.
- 机械性能 (拉伸强度,延伸) 被评估.
- 评估了子体内细胞毒性和体内伤口愈合.
主要成果:
- 合金的抗拉强度为258.4MPa,延长率为6.9%.
- 在HaCaT和L929细胞中没有观察到细胞毒性 (超过95%的活力).
- 在子中,Mg紧固件的伤口愈合效果与不钢紧固件的伤口愈合效果相当,没有组织刺激和减少长期保留.
结论:
- 这种新型的Mg皮肤主质是安全的,生物相容的,并且用于伤口关闭的功能.
- 基固剂与传统固剂同样有效.
- 一个关键的好处是减少长期保留的Mg主在伤口.
相关概念视频
Lipid Digestion
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
Protein Digestion
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Biodeterioration
Biodeterioration refers to the unwanted alteration of materials caused by microorganisms—especially fungi—which damage both organic substrates (paper, wood, textiles) and inorganic ones (stone, plaster, glass). Unlike abiotic decay, biodeterioration results from biological activity that produces physical disruption and chemical degradation.Physical deterioration occurs as fungal hyphae penetrate pores, cracks, and surface irregularities. Hyphal turgor pressure, thigmotropic growth along...
The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...


