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"两种基于酸盐的水泥在组织工程3D器官类型的叶纸模拟物上的生物反应"

A Koutrouli¹, F Machla², K Arapostathis¹

¹Department of Paediatric Dentistry, School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki GR-54124, Greece.

Dental materials : official publication of the Academy of Dental Materials

|March 2, 2024

概括

生物牙TM和矿物三氧化物聚合物 (MTA) 显示生物相容性,促进细胞生长和分化. 在牙纸模型中,BiodentineTM显示出更强的初始血管和牙反应.

科学领域:

生物材料科学生物材料科学
恢复性牙科恢复性牙科
细胞生物学细胞生物学

背景情况:

矿物三氧化物聚合物 (MTA) 和BiodentineTM是牙科中使用的基于酸盐的材料.
评估它们的生物反应对于了解它们在肉再生中的有效性至关重要.

研究的目的:

为了评估MTA和BiodentineTM在组织工程器官类型的树叶纸类似物上的生物反应.
为了比较这些材料对细胞活力,增殖,牙发育和血管发育标记物表达的影响.

主要方法:

使用人类内皮细胞 (HUVEC) 和牙干细胞 (SHED) 创建了一个三维纸模拟物.
将BiodentineTM和MTA的样本与纸类型直接接触.
分析了细胞活力,增殖,形态和特定标记物的基因表达.

主要成果:

这两种材料都支持细胞活力和形态学.
与MTA相比,BiodentineTM在第1天显著增加了细胞增殖,并且显示出更高的牙生成标记 (DSPP,BMP-2,RUNX2,ALP) 和血管生成标记 (VEGFa) 的上调调节.
此外,MTA还提高了牙生成标志物 (DSPP,BMP-2,RUNX2,Osterix,ALP) 和血管生成标志物 (ANGPT-1) 的调控.

结论:

无论是MTA还是BiodentineTM都具有生物相容性,并促进血管新生和口腔新生效应.
生物牙TM似乎会诱导更明显的初始细胞增殖,以及牙干细胞中更强烈的牙和血管生成反应.

关键词:

血管新生差异化差异化落叶牙是指落叶牙的一种牙.牙纸类似的牙纸.牙产生的差异化差异化基于酸盐的水泥.组织工程是组织工程.生命脉治疗生命脉治疗

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