查和早期检测在上胃肠道癌症中的作用
Jin Woo Yoo1, Monika Laszkowska1, Robin B Mendelsohn1
1Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Hematology/oncology clinics of North America
|March 2, 2024
概括
上部胃肠道癌症由于诊断延迟,预后不好. 针对高风险个体的查,考虑到癌前病变,对于早期检测和改善结果至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 上部胃肠道癌症是全球癌症死亡的主要原因之一.
- 延迟诊断显著导致这些癌症的预后不佳.
- 由于癌症发病率的变化,目前的普遍查往往不足于最佳水平.
研究的目的:
- 为应对早期检测上部胃肠道癌症的挑战.
- 为美国等适度发病率较低地区提出最佳查策略.
- 用人口,家庭和临床病理因素强调风险分层的作用.
主要方法:
- 对上部胃肠道癌症的发病率和风险因素的综述.
- 分析普遍查计划的局限性.
- 对高风险人群的有针对性的查方法的评估.
- 评估癌前病变的风险分层.
主要成果:
- 普遍查对所有人群来说都不是最佳的.
- 在发病率较低的地区,有针对性的查应集中在高风险人群上.
- 人口,家庭和临床病理因素是风险识别的关键.
- 癌前病变对于风险分层很重要.
结论:
- 有效查上部胃肠道癌症需要有针对性的方法.
- 识别高风险个体对于提高早期检测率至关重要.
- 评估癌前病变有助于风险分层和临床决策.
- 这种策略可以在上部胃肠道癌症管理中带来更好的患者结果.
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