溶解微针贴片制造中的创新冷干燥技术:提高通过皮肤递送药物的效率
Tong Su1, Zequn Tang1, Jiayi Hu1
1Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Drug delivery and translational research
|March 2, 2024
概括
这项研究引入了冷干燥技术,用于创建溶解微针贴片 (FD-MNP),与传统微制造相比,提供更快,更稳定的透皮药物输送方法. 对于像胰岛素输送这样的应用来说,FD-MNP证明了药物输送和稳定性的增强.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 微针贴片 (MNPs) 是通过皮肤传递药物,克服皮肤屏障的局限性有前途的.
- 溶解微针具有优势,但传统的微型制造具有长时间干燥和对湿度敏感等缺点.
- 当前制备方法的局限性阻碍了溶解微针的广泛发展.
研究的目的:
- 开发一种使用冷干燥技术制备溶解微针的新方法.
- 为了优化冷干燥微针贴片 (FD-MNP) 制造和增强其机械性能.
- 评估FD-MNP在通过皮肤递送药物的有效性和稳定性,使用胰岛素作为模型药物.
主要方法:
- 选适合用于冷干燥微针贴片 (FD-MNP) 制造的基材.
- 使用涂层技术来提高FD-MNP的机械强度和穿透皮肤的能力.
- 描述FD-MNP结构,机械性质,溶解率,以及体外/体内药物递送性能.
主要成果:
- 通过使用氨酸和胰岛素成功制备FD-MNP,呈现多孔结构.
- 实现了高机械强度 (0.61 N/针),97%的皮肤穿透率和215微米的穿透深度.
- 与传统的MNP相比,证明尖端溶解显著更快 (60秒对180秒),改善了通过皮肤递送的延迟时间,提高了胰岛素的生物可用性 (96.59%),以及优越的储存稳定性 (在40°C下2个月后95.27%的胰岛素含量).
结论:
- 冷干燥技术为生产溶解微针提供了一种可行和有利的方法.
- FD-MNP提供了更好的机械强度,更快的溶解,更高的药物输送效率和更好的稳定性.
- 这种新的方法具有很大的潜力,可以推进通过皮肤递送药物的应用.
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