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Jan Olsson1, Sema Nourmohammadi2, Emma Honkala2
1Department of Clinical Microbiology, Umeå University, Umeå, Sweden. jan.l.olsson@umu.se.
BMC infectious diseases
|March 2, 2024
概括
人类疹病毒1,2,爱斯坦-巴尔病毒和细胞巨乳病毒的血清流行率在年轻的瑞典出生队伍中正在下降. 这表明儿童和青少年感染这些常见病毒的风险降低.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 人类疹病毒在全球普遍存在,感染范围从无症状到严重的疾病.
- 血清发病率在不同人群和随着时间的推移而有显著的变化.
- 了解这些趋势对于公共卫生战略至关重要.
研究的目的:
- 确定免疫球蛋白G (IgG) 抗体对简单疹病毒1 (HSV-1),简单疹病毒2 (HSV-2),爱普斯坦-巴尔病毒 (EBV) 和细胞巨乳病毒 (CMV) 的血清流行率.
- 分析几十年来瑞典成年人口的血清流行趋势.
- 调查这些疹病毒的出生年份和血清流行率之间的相关性.
主要方法:
- 分析了来自生物库的892个血清样本,这些血清样本来自于1975年至2018年间出生的人.
- 样本来自30岁的女性,50岁的男性和女性.
- 使用线性和多线性回归分析来评估与出生年,年龄和性别的相关性.
主要成果:
- 在出生年和IgG患病率之间观察到HSV-1和EBV的负相关性.
- 发现出生年和CMV的IgG患病率之间存在正相关性.
- 对于30岁女性的HSV-1和HSV-2,以及50岁男性的CMV,注意到了特定的负相关性,晚期出生队伍的流行率下降.
结论:
- 针对HSV-1,HSV-2和EBV的IgG的血清流行率在最近的出生队伍中下降.
- 这一趋势表明,儿童和青少年感染这些特定的疹病毒的风险正在下降.
- 进一步的研究可以探索导致这些观察到的流行病学转变的潜在因素.
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