对老年人长期心理社会压力的全表观基因组相关性研究
Lauren A Opsasnick1, Wei Zhao1,2, Lauren L Schmitz3
1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Epigenetics
|March 3, 2024
概括
长期的心理社会压力会影响DNA甲基化,而健康行为只是这种效应的一小部分. 这表明其他机制将压力与表观遗传变化联系起来,影响健康结果.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 心理神经免疫学 心理神经免疫学
- 基因组学就是基因组学.
背景情况:
- 长期的心理社会压力与不良的健康结果和行为有关.
- 压力对表观基因组修饰的作用,特别是DNA甲基化,仍然在很大程度上未被探索.
- 假设健康行为是压力诱导表观遗传变化的关键调解者.
研究的目的:
- 调查累积心理社会压力和DNA甲基化在整个表观基因组之间的关联.
- 检查健康行为 (吸烟,饮酒,身体活动) 和体重指数 (BMI) 在压力-DNA甲基化关系中的调解作用.
主要方法:
- 对来自健康和退休研究的2689名参与者进行了一项全表观基因组关联研究 (EWAS).
- 在789,656个CpG位点使用Illumina Infinium HumanMethylationEPIC珠芯片评估了DNA甲基化.
- 进行调解分析以评估健康行为和BMI的作用.
主要成果:
- 确定了9个与心理社会压力显著相关的CpG位点 (p < 9E-07,FDR q < 0.10).
- 在八个CpG中,健康行为和/或BMI介导了9.4%至21.8%的压力甲基化相关性.
- 相关的CPG位于与心脏代谢特征,心理社会障碍,炎症和吸烟有关的基因附近.
结论:
- 心理社会压力与广泛的DNA甲基化变化有关.
- 健康行为只解释了压力和DNA甲基化之间的联系的一小部分,这表明了其他介导途径.
- 这些发现突显了慢性压力,表观遗传学和健康之间的复杂相互作用.
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