头发中的铁,铜和的度和食道癌症的风险:一个嵌套的病例对照研究
Maryam Hashemian1,2, Hossein Poustchi3, Maryam Sharafkhah3
1Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Archives of Iranian medicine
|March 3, 2024
概括
头发中较高的铁含量可能会增加食道状细胞癌 (ESCC) 的风险. 这项研究使用头发样本来评估矿物质状况及其与ESCC风险的关联,克服了饮食问卷的局限性.
科学领域:
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
- 生物标志物研究的研究.
背景情况:
- 以前的研究假设饮食中的铁,铜,和食道状细胞癌 (ESCC) 风险之间存在联系.
- 像食物频率问卷 (FFQ) 这样的饮食评估容易产生测量错误.
- 头发样本为长期矿物质状况提供了更可靠的生物标志物.
研究的目的:
- 通过头发样本评估的铁,铜和状况与ESCC风险之间的关联.
- 在营养流行病学中克服自我报告的饮食数据的局限性.
主要方法:
- 在戈勒斯坦队列研究中进行了一项嵌套病例控制研究 (大约. 有5万名参与者).
- 分析了96例ESCC病例和年龄匹配的对照,使用可用的头发样本.
- 感应合血质谱法 (ICP-MS) 测量了头发矿物质度.
- 用多种逻辑回归模型计算赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 病例中铁度的中位数 (35.4 ppm) 比对照组 (25.8 ppm) 高.
- 较高的铁状况与ESCC风险增加有显著的关联 (OR=1.41,95% CI=1.03-1.92).
- 没有发现铜或与ESCC风险的显著关联.
结论:
- 通过头发分析表明的铁水平升高,可能与食道状细胞癌 (ESCC) 的风险增加有关.
- 头发矿物质分析为研究营养状况和癌症风险之间的关系提供了宝贵的工具.
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