新生儿体外膜氧化:连续脏替代疗法,血小板减少和结果之间的关联
Lauren R Walker1, Laura E Hollinger1, W Michael Southgate1
1Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA.
Blood purification
|March 3, 2024
概括
在新生儿体外膜氧化 (ECMO) 期间的连续置换疗法 (CRRT) 与严重的血小板缺血有关. 然而,CRRT的使用也与这组患者的住院时间缩短有关.
科学领域:
- 新生儿重症监护室新生儿重症监护室
- 儿科重症监护医药 儿科重症监护医药
- 身体外膜氧化 (ECMO) 是一种
背景情况:
- 在接受ECMO,有或没有CRRT的新生儿中,血小板缺血的发生率和并发症尚未得到充分证实.
- 对ECMO治疗新生儿严重血小板缺血的危险因素的了解有限.
研究的目的:
- 在接受ECMO的新生儿中表征血小板缺血.
- 评估严重血小板缺血的风险因素,包括CRRT.
- 探索严重的血小板缺血与新生儿ECMO治疗结果之间的关联.
主要方法:
- 对在07/01/14至03/01/20期间接受ECMO的新生儿进行了回顾性单中心图表审查.
- 评估CRRT,严重血小板减少 (血小板数<50,000/mm3) 和结果 (ECMO持续时间,停留时间,存活率) 之间的关联.
主要成果:
- 严重的血小板缺血发生在52%的新生儿中,60%的新生儿同时接受CRRT.
- 接受CRRT与严重的血小板缺血有关.
- 接受CRRT的人住院时间较短,但ECMO持续时间,ICU停留时间和生存率没有差异.
结论:
- 在新生儿ECMO期间使用CRRT与严重的血小板缺血有关.
- 使用CRRT,出生体重和ICU位置是严重血小板缺血的潜在预测因素.
- 需要在更大的研究中进行进一步的调查.
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