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早期累积暴露于体重过重和中年认知功能:在三个英国出生队伍的纵向分析
Scott T Chiesa1, Tom Norris2, Victoria Garfield1
1Medical Research Council Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, UCL, London, UK.
The lancet. Healthy longevity
|March 3, 2024
概括
早期体重过重似乎不会直接影响中年人的认知功能,因为这种关联可能会被儿童的认知能力所混. 改善早期生活因素可能对体重和认知都有好处.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 中年过重的体重 (BMI>25 kg/m2;40-65岁) 与认知能力下降和痴呆风险有关.
- 早期 (<40岁) 体重过重对中年认知的影响尚不清楚.
研究的目的:
- 调查在生命早期累积的体重过重暴露和中年认知功能之间的双向路径.
主要方法:
- 对19,742名参与者的纵向分析 (出生于1946年,1958年,1970年的队列).
- 计算BMI轨迹 (10-40岁) 以确定体重过重的持续时间和累积暴露.
- 协调措施评估了儿童和中年人的认知功能 (口头,非口头,数学,阅读能力,回忆,命名,速度).
- 使用多变量回归和结构方程建模 (SEM).
主要成果:
- 青少年BMI增加和累积体重过重与中年认知能力较低有关.
- 在调整儿童认知功能后,这种关联减弱了,在考虑早期生活因素后,剩余的联系消失了.
- 儿童低认知预测了更高的累积体重过剩,可能是由童年不利因素介导的.
- SEM显示了从认知到以后的体重过重的适度路径,但很少有证据表明早期的体重过重影响中年认知.
结论:
- 早期体重过重和中年认知能力较低之间的联系很可能被持续的儿童认知功能所混.
- 针对弱势和教育等早期生活因素的干预措施可能为认知功能和体重管理提供双重好处.
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