化物组悬挂植入的基可注射水凝
De-Qiang Li1, Maryamgul Tohti1, Yong-Sheng Fu1
1College of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumchi 830052, Xinjiang, PR China.
International journal of biological macromolecules
|March 3, 2024
概括
这项研究引入了一种创新的方法,可以创建基组功能化的多糖,保持它们的结构,用于像注射水凝这样的先进应用. 这些水凝显示出出色的性能和生物相容性,用于药物输送.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 聚合物化学 聚合物化学
背景情况:
- 对于基功能化多糖的传统周期性氧化导致脊柱环开放,改变物理化学性质.
- 存在对维护多糖骨干完整性的方法的需求,以提高材料性能.
研究的目的:
- 开发一种用于基组功能化多糖的新方法,保留原生环状结构.
- 用于潜在的药物释放应用,从改性pectin制备可注射的水凝.
主要方法:
- 用环甲修改了pectin,从而产生了pectin aldehyde (AP).
- 通过希夫基反应,AP与DL-lysine (LYS) 交联,形成可注射的水凝.
- 福利埃变换红外光谱 (FT-IR) 和质子核磁共振 (1H NMR) 证实了功能化.
主要成果:
- 这种新的方法成功地功能化了pectin,同时保留了脊柱的环状结构.
- 由此产生的可注射水凝表现出良好的机械性能,自我愈合,注射性和持续释放性.
- 水凝表现出极好的生物相容性 (96%的细胞增殖),并且在充满药物时抑制癌细胞增殖.
结论:
- 建立了一种新的,结构保存的方法,用于 aldehyde组功能化的多糖.
- 开发的可注射水凝显示了先进药物输送系统的巨大潜力.
- 保持多糖骨干的完整性对于增强材料性能和功能至关重要.
更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
11.8K
09:39Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
7.9K
相关概念视频
02:51Metal-Ligand Bonds
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
00:43Complexometric Titration: Ligands
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...