脊髓的机械特性:一个系统的审查
Megan Stanners1, Marguerite O'Riordan1, Eirini Theodosiou2
1Aston Medical School, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.
概括
这一综述揭示了目前关于脊髓机械特性研究的重大局限性. 不一致的方法和研究质量差,特别是在动物模型中,阻碍了对活着的人类的准确应用.
科学领域:
- 生物力学 生物力学
- 神经科学是一个神经科学.
- 医疗工程 医疗工程
背景情况:
- 脊髓压缩是一种常见的临床问题,涉及病原和治疗的未解决问题.
- 目前的理解受限于缺乏对脊髓机械性质的现实世界测试.
- 现有的尸体和动物研究面临着方法和伦理方面的挑战.
研究的目的:
- 系统地审查有关脊髓机械性质的现有文献.
- 识别当前研究方法和研究结果中的差距和局限性.
主要方法:
- 对报告脊髓机械性质测试研究的系统文献综述.
- 使用ARRIVE指南,CAMARADES框架和SYRCLE的偏见风险工具评估方法质量.
主要成果:
- 以前的研究往往没有遵守动物待遇和偏见风险指南.
- 缺乏标准化的样品准备和机械测试协议,导致结果变化.
- 目前关于机械性能的数据不能可靠地应用于现存的人或动物.
- 动物试验是人类脊髓应用的不充分替代品.
结论:
- 目前关于脊髓机械性质的知识受限于方法上的不一致性和研究质量不佳.
- 为了准确的分析和测试,需要开发一个标准化的人类脊髓物理模型.
- 这种模型将促进进一步的临床研究,以改善脊髓压缩的结果.
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