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相关概念视频

Erythropoiesis01:14

Erythropoiesis

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Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
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Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
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循环核红细胞:一个更新的参考间隔.

Amy A Meredith1, Neil R Meredith2, Lynelle Smith3

  • 1From the Department of Biological Sciences, University of Denver, Denver, Colorado (AA Meredith).

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此摘要是机器生成的。

在健康成年人中,核化红细胞 (nRBC) 的上限可以安全地提高到0.10 × 10^6/μL. 这种对参考间隔的更新减少了与异常发现相关的不必要的患者焦虑和医疗费用.

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科学领域:

  • 血液学 血液学 血液学
  • 临床病理学 临床病理学
  • 实验室医学 实验室医学

背景情况:

  • 在健康的成年人中,核化红细胞 (nRBC) 通常不存在,传统的参考间隔 (RI) 设置非常低.
  • 当代分析仪在较低水平上检测到NRBC,导致健康个体经常出现异常标志.
  • 这引起了患者的焦虑,并增加了进一步调查的转诊.

研究的目的:

  • 评估NRBCs当前参考间隔的临床相关性.
  • 为了确定NRBCs的现有RI是否准确地反映了非住院患者的健康状况.

主要方法:

  • 对超过40万个完整血液样本 (CBC) 的前性分析.
  • 纳入/排除标准用于创建一个由来自健康,非住院患者的66,498个标本组成的研究池.
  • 对nRBC计数与已确定的RIs相关的分析.

主要成果:

  • 在健康人群中,0.5%的人 (66,498人中有336人) 的nRBC计数高于0.01×10^6/μL的传统RI.
  • 两个样本显示NRBC计数大于0.10 × 10^6/μL.
  • 在研究人群中,这些高NRBC计数与没有不良结局有关.

结论:

  • nRBC参考区间的上限可以安全地更新到0.10 × 10^6/μL.
  • 更新RI将减少不必要的患者焦虑,并通过尽量减少多余的后续测试来降低医疗保健成本.
  • 这种调整使实验室发现与健康人群的临床现实保持一致.